Platform

Thomas-Tran, R.; Du Bois, J. Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNav1.7Proc. Natl. Acad. Sci. USA 2016113, 5856.

Mulcahy, J. V.; Walker, J. R.; Merit, J. E.; Whitehead, A.; Du Bois, J. Synthesis of the Paralytic Shellfish Poisons (+)-Gonyautoxin 2, (+)-Gonyautoxin 3, and (+)-11,11-DihydroxysaxitoxinJ. Am. Chem. Soc. 2016138, 5994.

Thottumkara, A. P.; Parsons, W. H.; Du Bois, J. Saxitoxin. Angew. Chem. Int. Ed. 201453 (23), 5760-5784.

Walker, J. R.; Novick, P.; Parsons, W. A.; McGregor, M.; Zablocki, J.; Pande, V. S.; Du Bois, J. Marked Difference in Saxitoxin and Tetrodotoxin Affinities for the Human Nociceptive Voltage-gated Sodium Channel (NaV1.7). Proc. Natl. Acad. Sci. USA, 2012, 109, 18102-18107.

Mulcahy, J. V.; Du Bois, J. A Stereoselective Synthesis of (+)-Gonyautoxin 3. J. Am. Chem. Soc., 2008, 130, 12630-12631.

Fleming, J. J.; McReynolds, M. D; Du Bois, J. (+)-Saxitoxin: A First and Second Generation Stereoselective Synthesis. J. Am. Chem. Soc., 2007, 129, 9964-9975.


ST for Ocular Pain

Evaluation of NaV1.7 Inhibitors for the Treatment of Ocular Pain (click to open PDF)