Publications by SiteOne

Keenan, J.D.; Gonzales, J.A.; Waxman, S.G.; Delwig, A. Congenital Insensitivity to Pain: A Case Report with Corneal Esthesiometry and In Vivo Confocal Microscopy. Cornea. 2021.

Beckley, J.T.; Pajouhesh, H.; Luu, G.; Klas, S.; Delwig, A.; Monteleone, D.; Zhou, X.; Giuvelis, D.; Meng, I. D.; Yeomans, D. C.; Hunter, J. C.; Mulcahy, J. V. The antinociceptive properties of an isoform-selective inhibitor of Nav1.7 derived from saxitoxin in mouse models of pain. Pain. 2020.

Pajouhesh, H.; Beckley, J. T.; Delwig, A.; Hajare, H. S.; Luu, G.; Monteleone, D.; Zhou, X.; Ligutti, J.; Amagasu, S.; Moyer, B. D.; Yeomans, D. C.; Du Bois, J.; Mulcahy, J. V. Discovery of a selective, state-independent inhibitor of NaV1.7 by modification of guanidinium toxins. Sci. Rep. 2020, 10 (1), 14791.

Mulcahy, J. V.; Pajouhesh, H.; Beckley, J. T.; Delwig, A.; Du Bois, J; Hunter, J. C. Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaV1.7. J. Med. Chem. 2019, 62 (19), 8695-8710.


Publications by SiteOne Founders

Thomas-Tran, R.; Du Bois, J. Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNav1.7Proc. Natl. Acad. Sci. USA 2016113, 5856.

Mulcahy, J. V.; Walker, J. R.; Merit, J. E.; Whitehead, A.; Du Bois, J. Synthesis of the Paralytic Shellfish Poisons (+)-Gonyautoxin 2, (+)-Gonyautoxin 3, and (+)-11,11-DihydroxysaxitoxinJ. Am. Chem. Soc. 2016138, 5994.

Thottumkara, A. P.; Parsons, W. H.; Du Bois, J. Saxitoxin. Angew. Chem. Int. Ed. 201453 (23), 5760-5784.

Walker, J. R.; Novick, P.; Parsons, W. A.; McGregor, M.; Zablocki, J.; Pande, V. S.; Du Bois, J. Marked Difference in Saxitoxin and Tetrodotoxin Affinities for the Human Nociceptive Voltage-gated Sodium Channel (NaV1.7). Proc. Natl. Acad. Sci. USA, 2012, 109, 18102-18107.

Mulcahy, J. V.; Du Bois, J. A Stereoselective Synthesis of (+)-Gonyautoxin 3. J. Am. Chem. Soc., 2008, 130, 12630-12631.

Fleming, J. J.; McReynolds, M. D; Du Bois, J. (+)-Saxitoxin: A First and Second Generation Stereoselective Synthesis. J. Am. Chem. Soc., 2007, 129, 9964-9975.


Presentations

ARVO Annual Meeting 2018: Evaluation of NaV1.7 Inhibitors for the Treatment of Ocular Pain (click to open PDF)

IASP World Pain Congress 2018: Selective, State-Independent Inhibitors of Nav1.7 are Analgesic in a Non-Human Primate Model of Acute Thermal Pain (click to open PDF)