U.S. Department of Defense Awards Grant to SiteOne Therapeutics, Supporting Research and Development of Selective Small Molecule NaV1.7 Inhibitors as Acute and Chronic Pain Therapeutics

$1 Million Research Grant Helps Advance Existing Research and Development Partnership with Amgen

BOZEMAN, MT – The U.S. Dept. of Defense is supporting SiteOne Therapeutics in the effort to develop the company’s proprietary, highly selective small molecule Naᵥ1.7 inhibitors for the treatment of acute and chronic pain. 

In an announcement today, SiteOne Therapeutics Co-Founder and Vice President of Research, John Mulcahy, said “The validation and confidence of officials of the U.S. Department of Defense is exceptionally welcome.  There is a critical need for non-opioid therapeutics that treat acute and chronic pain effectively, allowing for less reliance on opioids, and reducing the side effects and addiction potential associated with them.  We are committed to advancing our research and development programs focused on Naᵥ1.7 and are inspired by the confidence of the many people and entities who support our approach.”

In January 2017, Stan Abel, Chief Executive Officer and President of SiteOne Therapeutics announced the closing of a research and development agreement with Amgen, a collaboration focused on combining SiteOne’s experienced drug discovery team and portfolio of novel Naᵥ1.7 inhibitors with Amgen’s neuroscience capabilities.  At the same time, Abel announced that SiteOne had closed a $15 million series B round of financing, led by Amgen and joined by founding investors Next Frontier Capital, 2M Companies Inc., Mission Bay Capital, Sears Capital Management, Biobrit LLC, and Z Investments.

About SiteOne Therapeutics

SiteOne Therapeutics was founded with technology licensed from Stanford University. The company has advanced this science with support from its founding investors as well as from the National Institutes of Health (NIH) which contributed more than $3 million in Small Business Innovation Research (SBIR) grant funding.

SiteOne Therapeutics is headquartered in Bozeman, Montana with a research team based in the San Francisco, California area.  Since its inception, SiteOne has been dedicated to developing novel pain therapeutics and diagnostics to safely, effectively and efficiently treat acute and chronic pain without the limitations of existing pain therapies, such as NSAIDs or opioids. The company’s therapeutic candidates are highly selective sodium ion channel 1.7 (Naᵥ1.7) inhibitors based on naturally occurring small molecules. Given the critical role Naᵥ1.7 plays in the generation and conduction of pain signals, combined with the urgent need for new, non-opioid pain therapies, SiteOne is focused on advancing its lead products for the treatment of moderate to severe pain.

DOD REQUIRED INFORMATION INCLUDED IN THIS PUBLIC ANNOUNCEMENT

The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office.  This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs, through the Broad Agency Announcement under Award No. W81XWH-17-1-0672. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense.  In conducting research using animals, the investigator(s) adheres to the laws of the United States and regulations of the Department of Agriculture.  In the conduct of research utilizing recombinant DNA, the investigator adhered to NIH Guidelines for research involving recombinant DNA molecules.  In the conduct of research involving hazardous organisms or toxins, the investigator adhered to the CDC-NIH Guide for Biosafety in Microbiological and Biomedical Laboratories.                               

SiteOne Therapeutics Appoints Debra Odink, Ph.D., As Chief Development Officer as the Company Advances Novel Pain Drug Candidates

Bozeman, Montana – SiteOne Therapeutics announced today the appointment of Debra Odink, Ph.D. as Chief Development Officer, leading the effort to advance the company’s innovative small-molecule Naᵥ1.7-based therapeutic candidates for acute and chronic pain. 

“Dr. Odink has a demonstrated track record of successfully leading the development of multiple drug candidates in a variety of therapeutic areas.” said Stan Abel, President and Chief Executive Officer, SiteOne Therapeutics.  “Her experience will significantly strengthen our team of exceptional scientists to accelerate the development of our novel Nav1.7 product candidates.”

Prior to joining SiteOne, Dr. Odink most recently served as Senior Vice President of Technical Operations at Eiger BioPharmaceuticals, Inc., where she was responsible for the manufacturing operations for multiple programs.  Prior to this she served as Chief Technical Officer and Senior Vice President at Anthera Pharmaceuticals responsible for non-clinical, clinical and manufacturing operations.  Earlier in her career Dr. Odink was Vice President of Pharmaceutical Chemistry and Product Development at Peninsula Pharmaceuticals (acquired by Johnson & Johnson in 2005) and served in the development organization for several years at Roche.

“Having worked with some of the world’s largest biopharmaceutical developers and with innovative start-up companies, it is clear to me that SiteOne Therapeutics has the talent, scientific acumen and commitment to improve the lives of patients,” said Dr. Odink.  “Given the opioid crisis in the United States and the lack of safe and effective alternatives for managing pain, I am excited to join the SiteOne team and to rapidly advance our drug candidates through preclinical and clinical evaluation.” 

In January of 2017, SiteOne Therapeutics announced its research and development agreement with Amgen, combining SiteOne’s experienced drug discovery team and portfolio of novel Naᵥ1.7 inhibitors with Amgen’s neuroscience capabilities.  As part of its partnership with Amgen, SiteOne closed its $15 million series B round of financing, led by Amgen and joined by founding investors Next Frontier Capital, 2M Companies Inc., Mission Bay Capital, Sears Capital Management, Biobrit LLC, and Z Investments.

SiteOne was founded with technology licensed from Stanford University. The company has advanced this science with support from its founding investors as well as from the National Institutes of Health (NIH) which contributed more than $3 million in Small Business Innovation Research (SBIR) grant funding.

About SiteOne Therapeutics

SiteOne Therapeutics is headquartered in Bozeman, Montana with a research team based in South San Francisco, California.  Since its inception, SiteOne has been dedicated to developing novel pain therapeutics and diagnostics to safely, effectively and efficiently treat acute and chronic pain without the limitations of existing pain therapies, such as NSAIDs or opioids. The company’s therapeutic candidates are highly selective sodium ion channel 1.7 (Naᵥ1.7) inhibitors based on naturally occurring small molecules. Given the critical role Naᵥ1.7 plays in the generation and conduction of pain signals, combined with the urgent need for new, non-opioid pain therapies, SiteOne is focused on advancing its lead products for the treatment of moderate to severe pain.

For more information, visit SiteOne’s Web site at www.site1therapeutics.com

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SiteOne Therapeutics Announces Research and Development Agreement With Amgen to Advance Portfolio of Highly Selective, Potent Inhibitors of Naᵥ1.7 for Acute and Chronic Pain

SiteOne Announces the Concurrent Closing of its $15 Million Series B Round of Financing

Bozeman, Montana – SiteOne Therapeutics announced today the signing of a new research and development agreement with Amgen combining SiteOne’s experienced drug discovery team and portfolio of novel Naᵥ1.7 inhibitors with Amgen’s neuroscience capabilities.

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he scientific achievements and warm memories of our friendships with George Miljanich live on with the team members and partners of SiteOne Therapeutics.

As a co-founder and Chief Scientific Officer of SiteOne Therapeutics, George brought more than 25 years of experience as an entrepreneur, inventor and scientist that empowered the people of SiteOne Therapeutics with an excellent foundation upon which to build. The seasoned leadership that George provided remains with the company every day as we move forward to help people struggling to more effectively treat acute and chronic pain with novel non-opioid based therapeutics.

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SiteOne Therapeutics Secures Investment from Bozeman-based Next Frontier Capital

Company Continues to Build Presence in Bozeman, MT as it Advances its Portfolio of Highly Selective Naᵥ1.7 Inhibitors for the Treatment of Pain

BOZEMAN, MONTANA, July 15, 2015 — SiteOne Therapeutics Inc. today announced the completion of an investment by Next Frontier Capital, a newly created venture fund in Bozeman, Montana with a focus on local technology-based companies. Joining Next Frontier are 2M Companies Inc. and all of SiteOne’s current investors, including Sears Capital Management, Biobrit LLC, Mission Bay Capital and Z Investments. This investment further reflects SiteOne’s expanded presence in Bozeman, Montana as the company continues to advance its platform of non-opioid therapeutics for acute and chronic pain. In conjunction with the financing, Will Price, founder and managing partner of Next Frontier Capital, will join SiteOne’s board of directors.

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