SiteOne Therapeutics Appoints Scott Braunstein, MD to Board of Directors

BOZEMAN, Mont., Sept. 12, 2018 /PRNewswire/ -- SiteOne Therapeutics, a private biopharmaceutical company advancing novel non-opioid pain therapeutics, today announced that Scott Braunstein, MD has been appointed to the Company's Board of Directors. Dr. Braunstein brings extensive leadership in sales, marketing and operations to SiteOne, as well as a successful track record of investing in biotech and pharmaceutical companies.

"We are very pleased to have Scott join our board of directors at such a pivotal time for SiteOne" said Stan Abel CEO of SiteOne Therapeutics. "Scott brings a wealth of experience in advancing and commercializing pain therapeutics. His experience in will be invaluable to our team as we continue to build SiteOne into a leading developer of non-opioid pain medicines."

Dr. Braunstein most recently served as the Chief Operating Officer at Pacira Pharmaceuticals. In this role Dr. Braunstein was responsible for overseeing sales, marketing, strategy and business development, playing an integral part in global licensing including securing a partnership with Johnson and Johnson in the United States for the Company's lead drug EXPAREL. During his time at Pacira, his roles included Chief Operating Officer, Chief Strategy Officer and SVP of Corporate Strategy and Development.

"I am honored to be appointed to the board of SiteOne Therapeutics and I look forward to working with my fellow board members and SiteOne's management team to help them accomplish their goal of developing a new class of effective non-opioid pain treatments" said Scott Braunstein.

Prior to Dr. Braunstein's role at Pacira, he served as a health care portfolio manager at Everpoint Asset Management. From 2002 through 2014 Dr. Braunstein was a healthcare analyst and managing director at J.P. Morgan Asset Management. Dr. Braunstein began his career as a practicing physician at the Summit Medical Group while also serving as assistant clinical professor at the Albert Einstein College of Medicine and for Columbia University Medical Center. Dr. Braunstein currently serves on the Board of Directors of ArTara Therapeutics and Esperion Pharmaceuticals and is an operating partner at Aisling Capital. Dr. Braunstein holds a bachelor's degree in business from Cornell University and earned his medical degree from the Albert Einstein College of Medicine.

About SiteOne Therapeutics, Inc.
SiteOne Therapeutics is a biopharmaceutical company headquartered in Bozeman, Montana with a research laboratory in South San Francisco, California. Since its inception, SiteOne has been dedicated to developing novel pain therapeutics to safely, effectively and efficiently treat acute and chronic pain without the limitations of existing pain therapies, such as NSAIDs or opioids. The company's therapeutic candidates are highly selective sodium ion channel 1.7 (Nav1.7) inhibitors based on naturally occurring small molecules. Given the urgent need for new, non-opioid solutions for managing pain, SiteOne is focused on advancing its lead product candidates for multiple therapeutic applications.

Contact:
Burns McClellan
Jill Steier, 212-213-0006
jsteier@burnsmc.com

 

SiteOne Therapeutics Appoints John Hunter, Ph.D. as Chief Scientific Officer

BOZEMAN, Montana, September 6th, 2018 — SiteOne Therapeutics, a private biopharmaceutical company advancing novel non-opioid pain therapeutics, today announced the appointment of John Hunter, Ph.D., as Chief Scientific Officer. Dr. Hunter is a highly-accomplished pharmaceutical research and development executive, having held multiple leadership positions within the pharmaceutical industry at Merck, Schering-Plough, Roche and Parke-Davis over the span of his 30-year career. In his role, Dr. Hunter will be responsible for advancing SiteOne’s portfolio of non-opioid drug candidates for the treatment of pain.

“John is a notable addition to our management team. His decision to join SiteOne at this stage in his career attests to our unique platform of first-in-class, highly potent and selective Nav1.7 inhibitors,” said Stan Abel CEO of SiteOne Therapeutics. “John has a wealth of knowledge in both neuroscience and drug development. His expertise will be invaluable as our pipeline of novel pain therapeutics progresses toward the clinic and our discovery platform continues to explore new indications.”

Prior to joining SiteOne Therapeutics, Dr. Hunter was most recently Vice-President of Research Science and Head of Discovery Research for the Cardio-Renal Therapeutic Area at Merck. Further roles within Merck included Vice President of Global Pharmacology, Screening & Protein Sciences and Vice-President and West Point Site Head for Discovery Research focused on the Neuroscience and Infectious Disease Therapeutic Areas. He was previously Vice-President of Neuroscience at Schering-Plough and Department Head of Pain Research and Systems Pharmacology at Roche Bioscience. During the course of his career, Dr. Hunter led multiple Discovery Research Project teams as well as early and late stage Clinical Development teams.

Dr. Hunter has published extensively, having authored more than 100 original scientific articles. He is currently a member of the International Association for the Study of Pain (IASP) and the Society for Neuroscience.

“SiteOne’s approach to targeting the Nav1.7 sodium ion channel is very unique and has tremendous potential to improve the standard of care in pain therapy,” said Dr. Hunter. “This is a very exciting time for SiteOne, and I look forward to working with the leadership team to achieve our goal of transforming the landscape of pain management.”

About SiteOne Therapeutics, Inc.
SiteOne Therapeutics is a biotechnology company headquartered in Bozeman, Montana with a research laboratory in South San Francisco, California.  Since its inception, SiteOne has been dedicated to developing novel pain therapeutics to safely, effectively and efficiently treat acute and chronic pain without the significant addiction potential and side-effects of opioids. The company’s therapeutic candidates are highly selective sodium ion channel 1.7 (Nav1.7) inhibitors based on naturally occurring small molecules. Given the urgent need for new, non-opioid solutions for managing pain, SiteOne is focused on advancing its lead product candidates for multiple therapeutic applications.

Contact:
SiteOne Therapeutics, Inc.
info@site1therapeutics.com

Investors:
Burns McClellan
Jill Steier, 212-213-0006
jsteier@burnsmc.com

SiteOne Therapeutics to Present Research Findings for Selective Small Molecule Nav1.7 Inhibitors at the 2018 World Congress on Pain

SiteOne Anticipates Filing IND for Lead Candidate by Year-End 2018

BOZEMAN, Montana, Thursday, July 19, 2018 — SiteOne Therapeutics, a private biopharmaceutical company advancing novel non-opioid pain therapeutics, announced today that the Company will present new preclinical data from its program developing novel selective small molecule Nav1.7 Inhibitors at the 17th World Congress on Pain®, scheduled to take place in Boston, Massachusetts, September 12-16, 2018. The poster will feature data supporting advancement of SiteOne’s lead candidate for which the Company expects to file an IND submission by year end 2018.

“We are pleased that our preclinical results will be featured in an international scientific meeting this year,” stated John Mulcahy, PhD, Co-inventor and Vice President of Research at SiteOne. “Since the inception of SiteOne Therapeutics, our team has prepared hundreds of new molecular entities targeting a unique binding site on Nav1.7.  Optimization of potency and selectivity has yielded compounds exhibiting nanomolar potency and >1000 fold selectivity over other isoforms.”

About Nav1.7

Nav1.7 is a voltage-gated sodium channel that plays a critical role in the generation and conduction of action potentials in sensory neurons and is required for the initiation of pain signals. Humans who are born with loss-of-function mutations in the gene encoding Nav1.7 cannot experience most types of pain, and conversely, those with a gain-of-function mutation of the Nav1.7 gene experience increased pain states. There has been immense interest in Nav1.7 channel blockers that have the potential to produce strong analgesia in acute and chronic pain while reducing the side effects associated with local anesthetics, opioids, or NSAIDs.

About SiteOne Therapeutics, Inc.

SiteOne Therapeutics is headquartered in Bozeman, Montana with a research laboratory in South San Francisco, California.  SiteOne is dedicated to developing novel pain therapeutics to safely, effectively and efficiently treat acute and chronic pain without the limitations of existing pain therapies, such as NSAIDs or opioids. The company’s therapeutic candidates are highly selective sodium ion channel 1.7 (Nav1.7) inhibitors based on naturally occurring small molecules. Given the critical role Nav1.7 plays in the generation and conduction of pain signals, combined with the urgent need for new, non-opioid pain therapies, SiteOne is focused on advancing its lead products to serve patients that suffer from moderate to severe pain.  For more information, visit SiteOne’s Web site at www.siteonetherapeutics.com.

Contact:
SiteOne Therapeutics, Inc.
info@site1therapeutics.com

 Investors:
Burns McClellan
Jill Steier, 212.213.0006
jsteier@burnsmc.com